Also, MgSO4 treatment significantly improved the RASS, Candida, SOFA, NIHSS and APACHE scores. Treatment with MgSO4 results in a significant reduction in serum levels of NGAL, Hb, T.Bill, IL-6, IL-8, SNSE, S100B, EGF, PAF, CRP and IgG. Routing biochemistry were also measured at days 1 and 5. Various severity test scores were used to evaluate the symptoms. Thirty-six patients with confirmed diagnosis of ischemic stroke and atrial fibrillation who received bolus amiodarone were randomly assigned to magnesium sulfate every 24 h or similar volume of normal saline (as placebo) for 5 days. We hypothesize that magnesium sulfate in combination with amiodarone holds promise for stroke treatment. However, amiodarone was accompanied with immunological pulmonary complications and adverse neurological effects. agents, like amiodarone, interfere at different stages of the ischemic stroke. 14 Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland. 13 School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. 12 Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
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11 Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.1 Pharmacotherapy Department, School of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran.
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9 Department of Biological Sciences, University of Limerick, Limerick, Ireland.8 Gastrointestinal Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.7 Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Tehran, Iran.6 Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.5 Department of Neurosurgery and Neurology, Sina Hospital, Tehran University, Tehran, Iran.4 Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.3 Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran.2 Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.1 Pharmacotherapy Department, School of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran.